Sparing men from infertility after chemotherapy
Alon Carmely and his team knew that AS101 had been shown to have chemoprotective effects in both animal and human studies, and they decided to investigate whether it could help avoid testicular damage in mice treated with Taxol. The results showed only minimal testicular damage in the group that had been injected with AS101. Mature sperm was also found, as opposed to the control group, in which the testicles showed severe atrophy and empty seminiferous tubules (where the sperm-producing cells are) .
This provides hope even for those men who did not freeze sperm prior to beginning chemotherapy - some for lack of time, some because they were simply unable to think that far ahead while dealing with the uncertainty of cancer.
Labels: male factor